Laser Ionization of Biologically Active Substances Using Zeolites

2014 Fiscal Year Final Research Report

• Project/Area Number: 24550030
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical chemistry
• Research Institution: Tokyo Metropolitan University
• Principal Investigator: TATSUYA Fujino 首都大学東京, 理工学研究科, 准教授 (20360638)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: レーザーイオン化法 / 酸化物固体表面 / ナノ微粒子 / 半導体 / 血清

Outline of Final Research Achievements

Zeolites are crystalline aluminosilicates with nanometer-order cages. Zeolites have high catalytic activity due to the charge imbalance at the Si-O-Al bridging sites, and those sites are compensated typically by such cations as H+ and Na+. Hydroxyl (OH) groups having Brönsted acidity exist in H+-exchanged zeolite. It is well known that the Brönsted acid site is responsible for the various catalytic activities of zeolite. In our recent research, we discovered that zeolite was also applicable to mass spectrometric studies. We have developed a “zeolite matrix,” which is a complex of organic MALDI matrix and zeolite. We succeeded in observing large ion peaks of analyte. In addition, we found that zeolite matrix is applicable to biologically active substances, which cannot be detected by conventional MALDI. We are fully convinced that the zeolite matrix can further improve the applicability of MALDI-MS.

Free Research Field

分光分析学