Development of Catalytic Method for Enantioselective Addition of Conventional Organometallic Reagents

2014 Fiscal Year Final Research Report

• Project/Area Number: 24550118
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Synthetic chemistry
• Research Institution: Kyoto Institute of Technology
• Principal Investigator: HARADA Toshiro 京都工芸繊維大学, 工芸科学研究科, 教授 (30135628)
• Co-Investigator(Kenkyū-buntansha): KUSUKAWA Takahiro 京都工芸繊維大学, 工芸科学研究科, 准教授 (70300720)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 合成化学 / 触媒 / 不斉合成

Outline of Final Research Achievements

The enantioselective addition of conventional organometallic reagents, such as organolithium, organozinc halides, organoboron, and organoaluminum reagents, to aldehydes is realized by the catalysis of chiral titanium complex derived from H8-BINOL derivatives bearing a bulky aryl group at the 3-position. As these organometallic reagents can be prepared readily from commercial precursors, a variety of enantiomerically enriched secondary alcohols are now available in a one-step reaction. The reaction of organozinc halides and organoboron reagents bearing functional group provides an access to the poly-functionalized chiral secondary alcohols that are often utilized in the asymmetric synthesis of pharmaceuticals.

Free Research Field

有機合成化学