Development of a boric acid-capturing molecular device using inositol ring inversion

2014 Fiscal Year Final Research Report

• Project/Area Number: 24550148
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional materials chemistry
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: YUASA Hideya 東京工業大学, 生命理工学研究科, 教授 (90261156)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 環反転 / リポソーム / 蝶番糖

Outline of Final Research Achievements

Monosaccharides like glucose have a foldable hexagonal structure. They can be exploited as a component of motional molecular devices, if we can control the folding structure by a signal molecule. We synthesized a monosaccharide with two long methylene chains that can change structures from linear to parallel chains by zinc ion. This monosaccharide with zinc ion forms a lipid bilayer structure by aggregation like cell membrane lipids, enabling incorporation of a lipophilic substance. In acidic conditions, this liposome structure is decomposed releasing the inner substances, because the parallel chain is turned back into the linear chain. The stimuli responsive liposome can be a new drug delivery system.

Free Research Field

生物有機化学