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2014 Fiscal Year Final Research Report

Development of a continuous-time method for intensity-modulated radiation therapy treatment planning

Research Project

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Project/Area Number 24560522
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Measurement engineering
Research InstitutionThe University of Tokushima

Principal Investigator

YOSHINAGA Tetsuya  徳島大学, ヘルスバイオサイエンス研究部, 教授 (40220694)

Project Period (FY) 2012-04-01 – 2015-03-31
Keywords強度変調放射線治療 / 最適化問題 / 微分方程式 / 非線形問題
Outline of Final Research Achievements

A novel approach of using nonlinear differential equations for solving box-constrained inverse problems in intensity-modulated radiation therapy (IMRT) treatment planning was proposed, and it was investigated through theoretical analysis, numerical analysis, creation of a prototype consisting of analog electronic circuits, and numerical experiments using phantom data simulating a clinical setup. Moreover, we presented a non-negatively constrained iterative method formulated by discretizing a differential equation in the continuous method. We give proofs for the convergence of a desired solution in the continuous and its discretized system, theoretically. When the IMRT inverse problem is well-posed, the proposed methods always provide an IMRT plan that exactly satisfies preset dose limits after sufficient time passage or iteration.

Free Research Field

医用工学

URL: 

Published: 2016-06-03  

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