Development of new aortic stent-graft materials by plasma technology that can control the surface morphology and the drug elution

2014 Fiscal Year Final Research Report

• Project/Area Number: 24560860
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Structural/Functional materials
• Research Institution: Tokai University
• Principal Investigator: HASEBE Terumitsu 東海大学, 医学部, 教授 (20306799)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Tetsuya 慶應義塾大学, 理工学部, 教授 (10286635)
• Co-Investigator(Renkei-kenkyūsha): HOTTA Atsushi 慶應義塾大学, 理工学部, 教授 (30407142)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 新機能材料 / 非晶質炭素膜 / リン脂質ポリマー / マイクロパターニング / 薬剤徐放 / プラズマ技術 / 細胞接着制御

Outline of Final Research Achievements

Endovascular aneurysm repair (EVAR) using a stent-graft is designed to help prevent an aneurysm from bursting. Endoleaks are characterized by persistent blood flow within the aneurysm sac following EVAR. In this study, to inhibit the endoleak inflow, we controlled the surface morphology and the drug elution of graft material by plasma technology, and we developed new materials for a graft fabric that enhanced cell adhesion and proliferation. As the specific results, we revealed that (1) the control of the surface morphology and the drug emission contributed to the proliferation of endothelial cells and that (2) micro-patterned hydrogenated amorphous carbon (a-C:H) coating on the polymer impregnated with basic fibroblast glows factor (bFGF) improved the endothelial cells growth rate.

Free Research Field

工学