Control of the internal and surface structures of biodegradable porous membranes with the aid of surfactants and their application to bioprocess

2015 Fiscal Year Final Research Report

• Project/Area Number: 24560957
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biofunction/Bioprocess
• Research Institution: Niigata University
• Principal Investigator: TANAKA Takaaki 新潟大学, 自然科学系, 教授 (00217043)
• Co-Investigator(Renkei-kenkyūsha): KAWASE Tomoyuki 新潟大学, 医歯学系, 准教授 (90191999)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 多孔質膜 / 生分解性材料 / 生体材料 / バイオプロセス / バイオセパレーション

Outline of Final Research Achievements

Biodegradable separation membrane and scaffold materials have been developed by controlling their internal and surface structures with the aid of surfactants. Asymmetric microporous separation membranes of poly(L-lactic acid) with pores in the order of 0.1 μm were prepared from the polymer solutions containing surfactants with the hydrophilic-lipophilic balance (HLB) values from 15.3 to 16.7. Osteoblast-like cells grew in the 500 μm-thick biodegradable microporous membranes when the cells were seeded on the rough side of the membranes.

Free Research Field

生物化学工学