Identification of a new type of monocytic cell that promotes affinity maturation and characterization of its B cell-activation mechanism

2014 Fiscal Year Final Research Report

• Project/Area Number: 24560961
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biofunction/Bioprocess
• Research Institution: Okayama University
• Principal Investigator: OHMORI HITOSHI 岡山大学, 自然科学研究科, 教授 (70116440)
• Co-Investigator(Renkei-kenkyūsha): MAGARI Masaki 岡山大学, 大学院自然科学研究科, 助教 (50359882)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 濾胞樹状細胞 / 単球系細胞分化 / CSF-1受容体 / IL-34 / CSF-1 / 細胞情報伝達 / 胚中心B細胞 / マイクロRNA

Outline of Final Research Achievements

B cells differentiate into high-afffinity antibody producers as the consequence of hypermutation immunoglobulin genes followed by selection of mutated clones. Follicular dendritic cells (FDCs) have been shown to play a pivotal role in these processes. To investigate immunologic functions of FDCs、we established an FDC line, FL-Y, which was shown to induce a new class of monocytic cells named FDMCs with a unique B cell stimulating activity. We found FDMC differentiation was strictly dependent on CSF-1 receptor (R) and the ligand, IL-34. This is the first report describing IL-34-selective CSF-1R signaling pathway.

Free Research Field

細胞工学・免疫学