2014 Fiscal Year Final Research Report
Analysis of regulatory mechanisms for the DNA damage tolerance pathway
| Project/Area Number |
24570010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Gakushuin University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HISHIDA Takashi 学習院大学, 理学部, 教授 (60335388)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | DNA損傷トレランス / DNA相同組換え |
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| Outline of Final Research Achievements |
Genomic DNA is constantly damaged by exposure to endogenous metabolic products and exogenous DNA-damaging agents. DNA replication stress caused by DNA damages potentially leads to genomic mutations and genome instabilities. On the other hand, replication stress can be abolished through the DNA-damage tolerance pathway. In this study, we analyzed a regulatory mechanism of DNA damage tolerance. Our findings indicate that dynamics of chromatin and novel factors are important for regulation of the DNA damage tolerance pathway.
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| Free Research Field |
分子生物学
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