2014 Fiscal Year Final Research Report
Molecular basis of nitric oxide action underlying the insect olfactory associative learning
Project/Area Number |
24570083
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Animal physiology/Animal behavior
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Research Institution | Tokyo Gakugei University |
Principal Investigator |
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | キノコ体 / ケニオン細胞 / イオンチャネル / 一酸化窒素 / cGMP / 嗅覚連合学習 |
Outline of Final Research Achievements |
Crickets have high capacity to form olfactory long-term memory. Previous studies have pointed to the importance of the nitric oxide (NO) signaling cascade in the formation of olfactory long-term memory within mushroom bodies. However,the mechanisms by which NO modulates neuronal excitability in mushroom bodies and results in the formation of LTM are not well understood. In the present study, we have revealed that NO increases the frequency and number of action potentials in Kenyon cells via modulation of various kinds of ionic channels including persisten Na, L-type Ca, Na-activated K, and BK channels.We conclude that NO acts as a modulator resulting in a stimulatory signal in Kenyon cells.
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Free Research Field |
神経生理学
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