2015 Fiscal Year Final Research Report
The role of lipid rafts in recognition of extracellular matrix remodeling by cancer cells
| Project/Area Number |
24570154
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 細胞・組織 / シグナル伝達 / 分子認識 |
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| Outline of Final Research Achievements |
Hyaluronan is a major component of the extracellular matrix and plays pivotal roles in inflammation and cancer. Lipid rafts are cholesterol- and glycosphingolipid-enriched membrane microdomains that may regulate membrane receptors while serving as platforms for transmembrane signaling at the cell surface. In this study, we demonstrated that lipid rafts regulate the interactions between hyaluronan and its receptor CD44, and control the cell adhesion and migration. Our results propose a possible molecular mechanism underlying cell migration. The regulation and manipulation of hyaluronan-CD44 interactions through lipid rafts have potential applications for the prevention of inflammatory disorders and cancer.
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| Free Research Field |
生物学
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