2014 Fiscal Year Final Research Report
The chromatin signaling regulates the formation of cell polarity.
Project/Area Number |
24570213
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cell biology
|
Research Institution | Osaka University |
Principal Investigator |
HIEDA Miki 大阪大学, 医学(系)研究科(研究院), 助教 (00380254)
|
Co-Investigator(Renkei-kenkyūsha) |
KURONO Sadamu (20271554)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | 核膜 / 細胞極性 / 乳癌 / LINC complex / 癌転移 / SUN1 / nesprin |
Outline of Final Research Achievements |
Formation of cell polarity plays fundamental roles in cell migration, cell differentiation, and carcinogenesis etc. The mammalian Golgi appratus has important function in the formation of cell polarity. In this study, we showed that histone methylation enzyme is required for proper Golgi structure via LINC (linker of nucleoskeleton and cytoskeleton) complex, a nuclear envelope protein complex consisting mainly of the SUN and nesprin protein families. In addition, we demonstrated global loss of a nuclear lamina component, lamin A/C and LINC complex components SUN1, SUN2, and nesprin-2 in breast cancer.
|
Free Research Field |
分子細胞生物学
|