Identification of nuclear pore complex proteins involved in nuclear differentiation of bi-nucleated unicellular organism Tetrahymena

2014 Fiscal Year Final Research Report

• Project/Area Number: 24570227
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cell biology
• Research Institution: National Institute of Information and Communications Technology
• Principal Investigator: IWAMOTO MASAAKI 独立行政法人情報通信研究機構, 未来ICT研究所バイオICT研究室, 主任研究員 (80450683)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 核膜孔複合体 / ヌクレオポリン / ２核性 / 繊毛虫 / テトラヒメナ / 核分化

Outline of Final Research Achievements

In this study, nuclear pore complex proteins of the binucleated unicellular organism Tetrahymena were comprehensively identified. Hereby, it became clear how some of the nuclear pore complex components were different between macronucleus and micronucleus. I studied the molecular functions of some components involved in generating of the structural difference between them, and successfully found probable components that had a major role in nuclear differentiation. This finding provides a new insight into understanding the mechanism that causes nuclear differentiation.

Free Research Field

細胞生物学