2014 Fiscal Year Final Research Report
Analyses of controlling factors in elongation movements
| Project/Area Number |
24570231
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Shuji 広島大学, 理学系研究科, 特任准教授 (90447318)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 形態形成 / 細胞運動 / 組織分化 |
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| Outline of Final Research Achievements |
I have studied about whether there are varieties in mechanisms of convergent extension regarding to cell directing role of tissue polarity. Xenopus neural, somitic and human dorsal mesoderm cell masses remained spherical shape in uniform differentiation states (= differentiation without tissue polarity), whereas the tissues elongated into direction of the polarity in biased differentiation states (= differentiation with tissue polarity). These results were consistent with previous experiments in Xenopus notochord tissue. Different combinations of signals induced the tissue polarity in different tissues. These results indicated that 1) "Tissue polarity is directing on convergent extension of the various vertebrate dorsal tissues" and 2) "Tissue polarity is induced by various combinations of signals".
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| Free Research Field |
発生生物学
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