2014 Fiscal Year Final Research Report
Comprehensive approaches to mechanisms underlying the development of blood islands in amphibian embryo
| Project/Area Number |
24570234
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Niigata University |
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Principal Investigator |
MAENO Mitsugu 新潟大学, 自然科学系, 教授 (10190315)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Takashi 早稲田大学, 教育・総合科学学術院, 教授 (80350388)
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| Co-Investigator(Renkei-kenkyūsha) |
KUMANO Gaku 東北大学, 生命科学研究科, 教授 (80372605)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 器官形成 / 両生類 / 骨髄球 / 中腎 / 血島 / 抗体 / 血管 / 心臓 |
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| Outline of Final Research Achievements |
The present research has attempted to elucidate development of the blood islands and myeloid cells in Xenopus embryo. First, we found a physiological role of Nkx2.5 and GATA4, which are the transcription factors for heart specification, are involved in the myeloid cell differentiation in the anterior blood islands. Second, we showed the distribution of Rdd (repeated D domain-like) protein in the developing embryo. Third, we discovered a novel population of myeloid cells in the mesonephric rudiment at an early tadpole stage.
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| Free Research Field |
発生生物学
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