Mechanism for rapid wound healing and initiation of regeneration

2015 Fiscal Year Final Research Report

• Project/Area Number: 24570239
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Developmental biology
• Research Institution: University of Hyogo
• Principal Investigator: MOCHII Makoto 兵庫県立大学, 生命理学研究科, 准教授 (90202358)
• Research Collaborator: OOSIGI Tadahiro ; YASUKAWA Shigehiro ; OKUMURA Akinari ; SATO Kentaro ; HARADA Seiya
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 尾部再生 / 傷修復 / 脊索 / 再生開始 / シグナル

Outline of Final Research Achievements

I analyzed wound healing and regeneration initiation after tail amputation using Xenopus tadpoles.
1. Analysis of notochord fragments grafted under host skin suggested that wounding of notochord, skin and muscle tissue is necessary to initiate notochord regeneration.
2. I established transgenic lines harboring egfp under control of xes1 promoter/enhancer, in which wound epidermis is labeled in situ. Pharmacological analysis using the transgenic tadpoles showed that TGF-β, ROS and ERK signals are required for both es1 expression and proper wound healing.

Free Research Field

発生生物学