2015 Fiscal Year Final Research Report
Elucidation of post-translational regulation of ABCG proteiins
| Project/Area Number |
24580139
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Kyoto Women's University (2014-2015)
Kyoto University (2012-2013) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | ABCタンパク質 / コレステロール / モジュレーター / 脂質 / トランスポーター / メタボリックシンドローム / 動脈硬化 / アルツハイマー病 |
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| Outline of Final Research Achievements |
The aim of this study is to elucidate lipid homeostasis in our body by analyzing post-translational regulation of ABCG proteins involved in lipid efflux from cells. Regulation mechanism of ABCG1 and ABCG4 in neuronal cells and functional regulation of ABCG proteins by fatty acids and interacting proteins were demonstrated. The results may lead to prevention and treatment of metabolic syndrome and Alzheimer’s disease.
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| Free Research Field |
生化学
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