2014 Fiscal Year Final Research Report
Search for Inhibitors of Amyloid beta Aggregation from Edible Plants and Their Mechanism
| Project/Area Number |
24580156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IRIE Kazuhiro 京都大学, 大学院農学研究科, 教授 (00168535)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | アミロイドβ凝集阻害活性 / アルツハイマー病 / Th-T / カフェ酸誘導体 / HGF産生促進活性 / サツマイモ / コーヒー / 神経細胞保護作用 |
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| Outline of Final Research Achievements |
Alzheimer’s disease (AD) is one of the most common forms of dementia. Amyloid β-proteins (Aβ) are considered to play an important role in the pathogenesis of AD. Caffeoylquinic acids (CQA) contained in the sweet potato and coffee, etc. exhibited potent inhibitory activity of the aggregation of Aβ. The catechol moiety in CQAs was indicated important role for the activity by structure-activity relationship of CQAs and related compounds. On the other hand, phenylethanoid glycosides included in the olive etc. were isolated as the active compounds using the Aβ aggregation inhibition test such as Thioflavin-T method. In addition, these Aβ aggregation inhibitors showed potent promotion activity of hepatocyte growth factor (HGF). Therefore, these bioactive compounds exhibit potent neuroprotective effect by their Aβ aggregation inhibitory activity, antioxidant activity, and HGF promotion activity.
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| Free Research Field |
天然物化学
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