2014 Fiscal Year Final Research Report
Synthetic study on a highly-substituted cyclic ring system including cyclobutane and a bioactive natural product causing hatching phenomenon toward potato cyst nematodes
| Project/Area Number |
24580161
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 天然物化学 / 有機化学 / 合成化学 |
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| Outline of Final Research Achievements |
Synthesis of solanoeclepin A, the most active hatching agent of potato cyst nematode isolated from hydroponic potato cultures was examined not only for the chemical supply of solanoeclepin A but also for the structure-activity relationship study. As a result, we have demonstrated the power of 4-exo-trig radical cyclization for construction of the highly strained cyclobutane found in solanoeclepin A. Since the substrate is readily prepared from Hajos-Parrish ketone, samarium(II)-mediated 4-exo-trig radical cyclization could provide one of the most straightforward accessible routes to the tricyclo[5.2.1.01,6]decane skeleton of solanoeclepin A.
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| Free Research Field |
農学
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