Effects of irregular eating on the hepatic inflammatory response in mice

2014 Fiscal Year Final Research Report

• Project/Area Number: 24580174
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Chiba University
• Principal Investigator: OARADA MOTOKO 千葉大学, 真菌医学研究センター, 助教 (40211784)
• Co-Investigator(Kenkyū-buntansha): GONOI Tohru 千葉大学, 真菌医学研究センター, 教授 (30134365)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 栄養学 / 食生活 / 肝臓 / 炎症

Outline of Final Research Achievements

Unhealthy eating behaviors increase the risk of metabolic diseases, but the underlying mechanisms are not fully elucidated. Because inflammation contributes to the pathogenesis of metabolic diseases, the objective of our present study was to address the effects of a fasting-refeeding regime, a model of irregular eating, on the hepatic inflammatory responses in mouse. Refeeding with a standard diet increased the liver expression of Tlr2 and proinflammatory mediators. These increases were attenuated in mice refed a low-carbohydrate/high-fat diet. TLR2 deficiency significantly attenuated the refeeding-induced increase in the liver expression of inflammatory genes. Dietary glucose, rather than fructose, plays a significant role in this increase. These findings suggest that an irregular eating behavior can elicit a liver inflammatory response, which is at least partly mediated by TLR2, and that dietary carbohydrates play critical roles in this process.

Free Research Field

栄養学