Regulation of intestinal epithelial glucose transporter by food factors to prevent or improve metabolic syndrome

2014 Fiscal Year Final Research Report

• Project/Area Number: 24580176
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Maebashi Institute of Technology (2014); The University of Tokyo (2012-2013)
• Principal Investigator: SATSU HIDEO 前橋工科大学, 工学部, 准教授 (80323484)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: トランスポーター / 腸管上皮細胞 / フィトケミカル / 生活習慣病 / 糖質

Outline of Final Research Achievements

We analyzed the food substances that inhibit intestinal monosaccharide absorption to prevent the diseases caused by excessive carbohydrates. We searched for phytochemicals that inhibit glucose transporter SGLT1, responsible for glucose absorption, and also GLUT5, responsible for fructose absorption. We found that tangeretin contained in citrus fruits and epicatechin gallate contained in green tea inhibited SGLT1 and GLUT5 activity. Oral glucose tolerance test using mice showed that tangeretin significantly suppressed the increase in mouse blood glucose level.

Free Research Field

食品機能学