2014 Fiscal Year Final Research Report
Glucose tolerance improvement effect of resistant starch -4: Is ileum and colon brake involved! ?
| Project/Area Number |
24580187
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Osaka Aoyama University (2013-2014)
Ehime University (2012) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | レジスタント スターチ タイプ４ / 耐糖性改善効果 / 血糖値 / インスリン / インクレチン / 短鎖脂肪酸 |
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| Outline of Final Research Achievements |
Resistant starch is highly resistant to α-amylase digestion and is subdivided into 4 categories (RS type 1- type 4). The use of RS enables fortification of many foods with a dietary fiber-like material. Resistant starch type 4 (RS-4) is chemically or physically modified starch and is used in many food industries to improve the physical properties of various products.
RS-4 showed an improving effect of glucose tolerance and a delaying effect of diabetes onset through stimulating the incretin secretion from the ileum and colon. The stimulating effect of RS-4 on incretin secretion was strongly related to the amount of short chain fatty acids produced by bacteria fermentaion of RS-4 in the large intestines. The incretin such as GLP-1 (glucagon-like peptide-1) and PYY (peptide YY)is hormone secreted from the gut in response to food and stimulates the secretion of insulin. The stimulating effect of RS-4 on incretin secretion depended on the degree of fermentation of the RS-4.
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| Free Research Field |
栄養科学
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