2014 Fiscal Year Final Research Report
Effect of collagen on the innate immune system.
| Project/Area Number |
24580188
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Ehime University |
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Principal Investigator |
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| Research Collaborator |
MATSUMOTO Yoshiteru 愛媛県認定漁業士協同組合, 理事長
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | コラーゲン / 自然免疫 / マクロファージ / 樹状細胞 / サイトカイン産生 / TLR4 |
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| Outline of Final Research Achievements |
The effects of collagen from jellyfish on the innate immune response, especially on the activity of macrophages were evaluated. The phagocytosis of macrophage was enhanced by collagen. Jellyfish collagen also stimulated tumour necrosis factor-α and interleukin-6 production of macrophages as the result of elevated gene expression levels of these cytokines. Oral administration of collagens elevated cytokine production by peritoneal macrophages in mice. On the contrary, collagen suppressed gene expression of PPARγ1 in macrophages. It is supposed from this result that collagen may stimulate the cytokine production by suppressing the PPARγ1 expression. The activity of jellyfish collagen was cancelled by TLR4 inhibitor. Moreover, jellyfish collagen stimulated phosphorylation of IκBα, promoted translocation of NF-κB, and activated JNK. Jellyfish collagen also activated and induced maturation of mouse bone marrow-derived dendritic cells.
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| Free Research Field |
食品機能学
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