2014 Fiscal Year Final Research Report
Appetite decreasing effect of soy isoflavone by novel mechanism via intestine
| Project/Area Number |
24580189
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Ehime University |
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Principal Investigator |
KISHIDA Taro 愛媛大学, 農学部, 教授 (80304658)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 食物繊維 / 摂取エネルギー / レプチン / 視床下部 / ラット |
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| Outline of Final Research Achievements |
Equol concentration in bile was higer than serum. The injected bile collected from rats fed daidzein significantly decreased food intake 12h after injection. After injection, the intestinal gene expression of CCK significantly increased and insignificant trend was observed in the gene expression of preproglucagon and peptide YY. Contrary to theresult in (2), we found that dietary equol decreased food intake regardress of CCKreceptor deficiency. CCK might not be a contributing factor in the mechanism of equol on decreased food intake in female rats.
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| Free Research Field |
栄養科学
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