2014 Fiscal Year Final Research Report
Effects of acetic acid on anti-obesity and anti-aging via its function for skeletal muscle
| Project/Area Number |
24580195
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Okayama Prefectural University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIMOTO Masumi 岡山県立大学, 保健福祉学部, 教授 (40108866)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 酢酸 / 脂質代謝 / エネルギー代謝 / 骨格筋 / 肥満 |
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| Outline of Final Research Achievements |
The purpose of this study was to investigate the interactive effects of acetate and exercise training on lipid metabolism and endurance performance. Six-week-old SD rats were randomly assigned to four groups: water-injected (rest-water), acetate-injected (rest-ace), exercise-trained after injection of water (water-ex), and exercise-trained after injection of acetic acid (acetate-ex). Body weight in acetate-ex groups was significantly lower than that of water-injected group. Acetate-ex group showed an increase of exercise capacity and lipid oxidation during exercise tolerance test. Skeletal muscle of rats treated with acetic acid and exercise training led to higher expressions of cytochrome c (cycs), and tended to stimulate expressions of PGC1a and MHC1 genes than those of rest-water group. Those results indicate that treatments both of exercise training and intake of acetate contribute to enhancement of lipid metabolism and improvement of exercise capacity.
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| Free Research Field |
食品栄養学
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