2015 Fiscal Year Final Research Report
Proteomic analysis of bioactive substances coexisted with a multifunctional milk protein and application of the biological functions
| Project/Area Number |
24580197
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | Kyoritsu Women's University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Keywords | 食品機能 |
|---|
| Outline of Final Research Achievements |
Although a single substance, lactoferrin is known as being extremely multi-functional. We investigated the possibility that, besides the multi-functionality derived from the lactoferrin itself, lactoferrin expressed behaviors in conjunction with other bioactive components. Impurities in lactoferrin used as a reagent and food ingredient were fractionated using multi-stage methods, including affinity chromatography and ion exchange chromatography. The proteins and peptides present were examined using MALDI-TOF-MS proteomic analysis. Several components that exhibit bioactive characteristics, including immunomodulating effects and osteoblast proliferation were present among the impurities.
|
| Free Research Field |
農学
|
