The effects of UVB irradiation to the skin on metabolic syndrome

2014 Fiscal Year Final Research Report

• Project/Area Number: 24580199
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Tokyo University of Agriculture
• Principal Investigator: OISHI Yuichi 東京農業大学, 応用生物科学部, 教授 (00313073)
• Research Collaborator: MATUSI Sho
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 紫外線 / 皮膚 / CGRP / TGF-β1 / 急性期タンパク質 / インターロイキン-6 / アディポネクチン / PAI-1

Outline of Final Research Achievements

We investigated the mechanisms that the irradiation of ultraviolet B (UVB), which is a major environmental factor that affects the structure and function of the skin, decreases the blood adiponectin level and plasminogen activator inhibitor (PAI)-1. Our results showed that the exposure of skin to UVB decreased the blood protein and adipose mRNA levels of adiponectin through the endocrine action of serum amyloid A increased by the activation of calcitonin gene-related peptide (CGRP) signals possibly via the skin-brain-liver axis. Furthermore, CGRP inhibited TGF-β1-induced expression of PAI-1 by decreasing the phosphorylation status of the MAP kinase pathway through activating the cAMP/protein kinase A pathway. UVB signals have both negative and positive effects such as a decline of skin function and alleviation of hepatic fibrosis, respectively. Therefore, our study would contribute to the elucidation of mechanisms underlying the endocrine and neuroendocrine functions of skin.

Free Research Field

栄養生化学　皮膚科学