Study of the functional molecules of the intestinal immune system for the inductive or regulative responses in the colon

2014 Fiscal Year Final Research Report

• Project/Area Number: 24580200
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Nihon University
• Principal Investigator: HOSONO Akira 日本大学, 生物資源科学部, 教授 (70328706)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Kyoko 日本大学, 生物資源科学部, 准教授 (70366574)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 腸内細菌 / 大腸 / 免疫

Outline of Final Research Achievements

Although there are huge numbers of the commensal bacteria in the large intestine compared with the small intestine, the regulatory immune system, which was controlled for the prevention of the sensitive inflammatory reaction in the large intestine, was not understood. In this study, we have investigated to clarify the characteristics of the immune system in the large intestine. We have clarified that there are fewer expression of CD3 and activated CD4 T cells in the colonic patch cells compared with those in Peyer’s patch cells. In the germ-free mice, the frequency of these phenotypes was observed to be fewer than those in conventional mice. We have demonstrated that the frequency of the activated CD4 T cells were down-regulated in the large intestine than that in the small intestine.

Free Research Field

食品機能学