The regulation of DNA damage response by foods or its ingredients

2014 Fiscal Year Final Research Report

• Project/Area Number: 24580203
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Nigata University of Phermacy and Applied Life Sciences
• Principal Investigator: NISHIDA HIROSHI 新潟薬科大学, 応用生物科学部, 教授 (60322541)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ATM / ATR / Checkpoint / food extracts / flavonoid / gomisin-N

Outline of Final Research Achievements

ATM and ATR protein kinases play a crucial role in cellular DNA damage responses. The inhibition of these kinases and related molecules lead to an abolishment of one such signal pathways termed as ”checkpoints”. It is expected that the discovery of checkpoint modulator will be an effective assistance of anti-cancer therapy. We discovered several candidates from foods including resourses of traditional medicines. Gomisin-N and Persimmon leaf foavonols (PLF) inhibited ATR and ATM in vivo and in vitro, respectivly. The inhibitory effect of PLF was observed in xenograft mice which irradiated with heavy ion carbon beam. Addition, we discovered some food stuffs which inhibit tumor cell growth such as 3,4-dihydroxybenzalacetone, feruic acid/gamma-tocotorienol and phosphatidylcholine peroxide. Here, we revealed anti-cancer effects of ingrients of foods, and clarified detailed mechanisms of intracellular signal regulation.

Free Research Field

Nutritional biochemistry