Elucidation of the functionality of the phytoestrogen-metabolizing intestinal bacteria

2014 Fiscal Year Final Research Report

• Project/Area Number: 24580206
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: National Agriculture and Food Research Organization
• Principal Investigator: TAMURA Motoi 独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所食品機能研究領域, 上席研究員 (70353943)
• Co-Investigator(Kenkyū-buntansha): NAKAGAWA Hiroyuki 独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所・食品安全研究領域, 主任研究員 (30308192)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: フィトエストロゲン / エコール / ダイゼイン / 植物リグナン / エンテロジオール / マウス / 腸内菌叢 / 脂質代謝

Outline of Final Research Achievements

Soy isoflavone and plant lignan are belong to the phytoestrogens. In this study, we found that the administration of equol-producing bacteria to the mice fed the diet containing daidzein and plant lignan increased the equol production as compared to the mice administrated physiological saline. Co-administration of three lignan-metabolizing bacteria and two isoflavone-metabolizing bacteria to the mice increased the enterodiol production as compared to the mice administrated physiological saline. Our results suggest that the administration of lignan-metabolizing bacteria to the mice fed the diet containing daidzein and plant lignan affects the lipid metabolism of mice differently from the administration of lignan-metabolizing bacteria plus isoflavone-metabolizing bacteria to the mice fed the diet containing daidzein and plant lignan.

Free Research Field

農学