2014 Fiscal Year Final Research Report
Search of the molecular marker concerned with seafood allergic disease and the application to an allergenicity evaluation
| Project/Area Number |
24580301
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | Tokyo University of Marine Science and Technology |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | アレルギー / 食品 / アレルゲン / 魚介類 / 遺伝子発現 |
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| Outline of Final Research Achievements |
Seafoods, including fish, crustaceans and mollusks, are well recognized as one of the most common causes of food allergy mediated by immunoglobulin E antibodies. However, the mechanism concerning to onset of seafood allergy is not elucidated, and the details of the gene expression in conjunction with the onset are not clarified.
Therefore, in this study, seafood allergy model mouse was constructed for the purpose of the identification of the gene cluster about onset of seafood allergy. As a result, the gene which the expression increased was specifically identified in case of the onset of seafood allergy by the cDNA subtraction method. It was revealed that a kind of cytokine called interleukin-5 specifically participated in the onset of seafood allergy.
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| Free Research Field |
水産化学
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