2015 Fiscal Year Final Research Report
Effect of docosenoic acid and icosenoic acid on the type 2 diabetic mellitus and atopic dermatitis.
| Project/Area Number |
24580305
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | Miyagi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOMIOKA Yoshihisa 東北大学, 薬学研究科, 教授 (00282062)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 脂質 / 水産利用学 / サンマ / ドコセン酸 / イコセン酸 / 2型糖尿病 / アトピー性皮膚炎 |
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| Outline of Final Research Achievements |
We investigated the effect of docosenoic acid and icosenoic acid, the abundant monounsaturated fatty acids in the saury oil, on the type-2 diabetic mellitus and atopic dermatitis. Supplementation with docosenoic acid and icosenoic acid had reduced Atopic dermatitis like skin lesions and the frequency of scratching episodes in a time-dependent manner on atopic NC/Nga mice. Furthermore, docosenoic acid and icosenoic acid had reduced weight and insulin sensitivity had improved on the type-2 diabetic KK-Ay mice. From these results, it appears that docosenoic acid and icosenoic acid can contribute to the prevention of a lifestyle-related disease and the allergic disease.
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| Free Research Field |
農学
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