Studies on mechanisms responsible for inhibin's action

2014 Fiscal Year Final Research Report

• Project/Area Number: 24580421
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: ARAI Koji 東京農工大学, 農学部, 准教授 (70293016)
• Co-Investigator(Renkei-kenkyūsha): NISHIYAMA Toshio 東京農工大学, 農学部, 教授 (60372455)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: インヒビン / 卵胞刺激ホルモン / アクチビン / フォリスタチン

Outline of Final Research Achievements

Inhibin, a member of the TGF-beta superfamily, regulates ovarian follicular development by specifically suppressing follicle-stimulating hormone secretion. It is suggested that inhibin suppresses FSH secretion by destabilizing FSH beta mRNA through its 3' untranslated region (3'UTR). Therefore, we have developed a mouse strain lacking the 3'UTR, and we are now analyzing characteristics of this strain. Furthermore, we developed a CHO cell line secreting rat recombinant inhibin to investigate mechanisms responsible for inhibin's action.

Free Research Field

基礎獣医学