Studies on the switching mechanism for energy source lipid in the chicken liver around hatching

2014 Fiscal Year Final Research Report

• Project/Area Number: 24580434
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Nippon Veterinary and Life Science University
• Principal Investigator: TANAKA Minoru 日本獣医生命科学大学, 応用生命科学部, 教授 (90024736)
• Co-Investigator(Renkei-kenkyūsha): 太田 能之 日本獣医生命科学大学, 応用生命科学部, 教授 (00277667) ; 中尾 暢宏 日本獣医生命科学大学, 応用生命科学部, 講師 (60377794)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脂質代謝 / ニワトリ肝臓 / コレステロールエステル / 胆汁酸輸送 / コレステロール合成 / ニューロテンシン受容体 / プロラクチン受容体

Outline of Final Research Achievements

In the chicken liver, expression of cholesterol acyltransferase mRNA decreased after the hatching, whereas expression level of mRNA of the lysosomal acid lipase temporarily increased after the hatching. In the intestinal tract, expression level of bile acid transporter mRNA markedly increased after the hatching. In the liver, neurotensin receptor and acetoacetyl-CoA thiolase-2 increased after the hatching, Expression level of prolactin receptor mRNA was high before the hatching and decreased after the hatching. It was suggested that these enzymes and hormones are involved in the conversion of the energy source from the cholesterol ester in the liver to the external diet after the hatching.

Free Research Field

エネルギー代謝