2014 Fiscal Year Final Research Report
The effect of hypertension on diabetic peripheral neuropathy in diabetic animal model.
| Project/Area Number |
24580438
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Basic veterinary science/Basic zootechnical science
|
|---|
| Research Institution | Setsunan University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MATSUURA Tetsuro 摂南大学, 薬学部, 教授 (20268494)
KODAMA Yasushi 広島国際大学, 薬学部, 講師 (40389119)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 糖尿病 / 末梢神経 / モデル動物 / 糖尿病末梢神経症 / 高血圧 |
|---|
| Outline of Final Research Achievements |
To investigate the effects of hypertension by Deoxycorticosterone(DOCA) and saline on diabetic peripheral neuropathy, we examined the peripheral nerves of alloxan-induced diabetic WBN/Kob rats. Hypertension and vascular lesions of peripheral nerves were induced in DOCA group, but there was no effect on nerve lesions. However, in saline group, vascular and nerve lesions were deteriolated. These findings indicate that saline-induced hypertension have effect on diabetic peripheral neuropathy.
|
| Free Research Field |
病理学
|
