Basic study for assembling the picture of Borna Virus Infection

2015 Fiscal Year Final Research Report

• Project/Area Number: 24580442
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied veterinary science
• Research Institution: Hokkaido University
• Principal Investigator: Otsuka Yayoi 北海道大学, (連合)獣医学研究科, 客員研究員 (30396303)
• Co-Investigator(Kenkyū-buntansha): SATO Kota 北海道大学, 大学院獣医学研究科, 准教授 (50283974)
• Co-Investigator(Renkei-kenkyūsha): INABA Mutsumi 北海道大学, 大学院獣医学研究科, 教授 (00183179)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: ボルナ病ウイルス

Outline of Final Research Achievements

Borna disease virus (BDV) establishes persistent infection in the central nervous system and causes behavioral disturbances in several animal species including humans. BDV glycoprotein (BDVG) expression is extremely low in cells persistently infected with BDV and cells transfected with BDVG cDNA. Recently, avian bornavirus (ABV) was identified in parrots. In this study, we characterized ABV glycoprotein (ABVG) and reported that the expression of ABVG in transfected cells was remarkably higher than that of BDVG, despite similarities in their polypeptide backbone. We also showed that the amino acid sequence of the transmembrane domain affected plasma membrane expression levels of BDVG, and suggested the possible roles of host splicing factors in modulating the expression levels of BDVG.

Free Research Field

獣医学