Genetic analysis of a new Mycobacterium tuberculosis complex species possessing a wide host range

2014 Fiscal Year Final Research Report

• Project/Area Number: 24580443
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied veterinary science
• Research Institution: Hokkaido University
• Principal Investigator: NAKAJIMA Chie 北海道大学, 人獣共通感染症リサーチセンター, 准教授 (60435964)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Yasuhiko 北海道大学, 人獣共通感染症リサーチセンター, 教授 (90206540)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 結核菌群菌 / Mycobacterium orygis / 人獣共通感染症 / バングラデシュ / ネパール

Outline of Final Research Achievements

A new Mycobacterium tuberculosis complex (MTC) species named Mycobacterium orygis, which seems to possess a wide host range, was isolated from lung TB regions in several animal species in Bangladesh and Nepal. Molecular characterizations of those isolates suggested the wide prevalence of M. orygis among wild animals in those areas. In Nepal, several M. tuberculosis isolates were obtained from captive elephants and some small structural changes by activated transposons were observed in their genomes. Analyses of those affected regions on the genomes together with comparative genomic analyses of M. orygis derived from different host species will provide us insights into the genetic regions associating with host range determination in MTC.

Free Research Field

人獣共通感染症学