2014 Fiscal Year Final Research Report
Development of diagnostic methods for early and prognosis of mycobacterial infection
Project/Area Number |
24580448
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied veterinary science
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Research Institution | University of Miyazaki |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
HAGA Takeshi 東京大学, 大学院農学生命科学研究科, 准教授 (20315360)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | 豚 / 抗酸菌 / 感染症 / 診断 / サイトカイン / mycobacterium / avium / hominissuis |
Outline of Final Research Achievements |
Mycobacteriosis of pigs caused by Mycobacterium avium subsp. by hominissuis (Mah) is an infectious disease which forms the granulomatous lesions similar to tuberculosis in visceral organs. So far only discovery by the naked eye of veterinarians in slaughterhouses has become a decisive diagnosis and such infectious organs have been discarded. Therefore, it appears to be necessary to develop a new diagnostic method. We has been looking for the cytokines which were induced by Mah infection. Qualitative or quantitative assay of these cytokines seems to be useful for diagnosis of porcine mycobacterial infection. We found several cytokines as candidates. Types and amounts of cytokines produced varied with the time of Mah infection and progress of the disease. We are currently being developed for diagnosis of infectious conditions utilizing the difference in the inducing pattern of these cytokines in the infected pigs.
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Free Research Field |
獣医微生物学
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