2014 Fiscal Year Final Research Report
Study on endophthalmitis treatment of nano-particles of ophthalmic drugs: anti-inflammatory effect and its mechanism
| Project/Area Number |
24580464
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ナノ化物質 / 眼内炎 / 転写因子 / 抗炎症薬 |
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| Outline of Final Research Achievements |
We evaluated the anti-inflammatory effect of 0.5% tranilast nanoparticles (TLn) eyedrops on endotoxin-induced uveitis (EIU) in rats and lipopolysaccharide (LPS)-induced inflammatory response and the underlying mechanisms in RAW264.7 cells. The present results demonstrate that the topical instillation of TLn eyedrops suppresses the inflammation in EIU. The possible mechanisms for the effect of TLn may dependent on the ability to inhibit the activation of NF-κB pathway through p-IKK and/or IκB degeneration and association of early HO-1expression and activation protein (AP)-1 pathway through p-JNK and subsequent expression of proinflammatory mediators. These findings suggest that TLn may be promising agent for the management of inflammation including ophthalmologic field.
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| Free Research Field |
獣医眼科学
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