Development of a regenerative therapy for spinal cord injury by autologous transplantation of bone marrow derived mononuclear cell.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24580469
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Clinical veterinary science
• Research Institution: Nippon Veterinary and Life Science University
• Principal Investigator: HARADA Yasuji 日本獣医生命科学大学, 獣医学部, 准教授 (70398882)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 再生医療 / 脊髄 / 骨髄 / 単核細胞

Outline of Final Research Achievements

As a regenerative therapy of a spinal cord, the various types of cell therapy were developed. Autologous transplantation of bone marrow-derived mononuclear cell is useful for early transplantation after injury without a cell culture. Our clinical trials, using an autologous transplantation of bone marrow-derived mononuclear cells, showed therapeutic effect for the spinal-cord-injury case of dogs. Since most mechanisms in which the transplanted bone marrow-derived mononuclear cell regenerate a spinal cord were not explored, we examined by using a rat model. As a result, the transplanted bone marrow-derived mononuclear cells existed in the injected area for over one week. Cytokines, such as HGF, MPC-1, and VEGF were secreted from transplanted bone marrow-derived mononuclear cells. These cytokines believed to reduce the apoptosis of nerve cells, and having a protective effect for injured spinal cord.

Free Research Field

臨床獣医学