Asymmetric syntheses of biologically active heterocyclic natural products employing catalytic C-H activation strategy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590001
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: University of Toyama
• Principal Investigator: NAMBU Hisanori 富山大学, 大学院医学薬学研究部(薬学), 准教授 (80399956)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 複素環化合物 / C-H結合活性化 / 生物活性天然物 / C-H挿入反応 / 触媒反応 / ロジウム(II)錯体 / 不斉合成 / ジヒドロベンゾフラン

Outline of Final Research Achievements

Asymmetric synthesis of (－)-trans-blechnic acid, a dihydrobenzofuran neolignan natural product, has been achieved by employing Rh(II)-catalyzed intramolecular C-H insertion reaction of aryldiazoacetate and Pd(II)-catalyzed intermolecular C-H olefination reaction as key steps.
Asymmetric synthesis of (－)-E-δ-viniferin, a trans-resveratrol dimer natural product containing a dihydrobenzofuran ring, has been achieved by exploiting Rh(II)-catalyzed intramolecular C-H insertion reaction of a diaryldiazomethane derivative as a key step.

Free Research Field

有機合成化学