2014 Fiscal Year Final Research Report
Development of Organic Reactions Using New 1,4-Zwitterionic Intermediates
| Project/Area Number |
24590007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 有機化学 |
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| Outline of Final Research Achievements |
We found that 1,4-zwitterionic intermediates which were formed by Lewis acid-mediated ring cleavage of 3-alkoxy or 3-aminocyclobutanones reacted with indoles at their C2-C3 double bonds to afford the corresponding hydrocarbazoles. We accomplished total synthesis of racemic aspidospermidine and synthesis of partial structure of racemic strictamine by using the above-mentioned cycloaddition reaction.
Furthermore, we accomplished optically active thromboxane B2 by using formal [4+2] cycloaddition reaction between a 3-alkoxycyclobutanone and an aldehyde.
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| Free Research Field |
有機合成化学
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