Development and application of the cyclic carbon framework construction by the catalytic domino type reactions

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590012
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Nagasaki University
• Principal Investigator: KURIYAMA Masami 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 (40411087)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 合成化学 / Ｎ-ヘテロ環状カルベン / パラジウム / 触媒反応 / 複素環

Outline of Final Research Achievements

The development of efficient methods and effective ligands for catalytic synthesis of useful compounds was conducted. First, the one-pot synthetic method for ketones through palladium-catalyzed 1,2-addition and oxidation was achieved with the thioether-imidazolium chlorides. In this catalytic transformation, various monoheteroaryl and diheteroaryl ketones were prepared with high efficiency. Then, we developed novel ether-imidazolium chlorides as ligand precursors for transition metals. The palladium/ether-imidazolium chloride system realized the efficient synthesis of various biheteroaryls from heteroaryl chlorides and heteroaryl boron reagents.

Free Research Field

薬学・化学系薬学