2014 Fiscal Year Final Research Report
Synthesis and Activity of Tea Catechins Lactone-Metabolite
| Project/Area Number |
24590014
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Toyama Prefectural University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 茶カテキン / 代謝物 / γ-ブチロラクトン化合物 / ガン細胞増殖阻害増強効果 / 白血病細胞HL-60 |
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| Outline of Final Research Achievements |
Tea catechins such as epicatechin, epigallocatechin, epicatechin gallate and epigallocatechin gallate changes many metabolites including γ-valerolactone compounds through metabolic pathways in the human body.
Fourteen of these γ-valerolactone metabolite analogues were synthesized as the optically active authentic standards and these activities are examined. Furthermore, we found out that the mixture of EGCG (flavan-3-ol) and its metabolite γ-valerolactone compounds inhibit proliferation of HL-60 cells, human promyelocytic leukemia cells.
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| Free Research Field |
有機合成化学
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