2014 Fiscal Year Final Research Report
Total Synthesis of Naphthacemycins, Possession of Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus (MRSA)
| Project/Area Number |
24590019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | MRSA / Naphtacemycin / 全合成 / デッツ反応 |
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| Outline of Final Research Achievements |
The MRSA is typical drug-resistance bacterium, which has recently become a one of the social problem as infecting organism of nosocomial infection. Now, there are some of anti-MRSA drugs, but development of new anti-MRSA drugs is still required due to emergence new drug resistance bacterium. As a result of searching for the new anti-MRSA drug at the Kitasato Institute, novel naphthacemycins have been isolated from the culture broth of streptomyces sp. Bioactivity of these compounds is potentiate activity of imipenem against MRSA, and some of naphthacemycins possess antibacterial activity. Especially naphthacemycin A8 and A9 have potent antibacterial activity against MRSA. The structural feature of naphthacemycins consist of tetracene structure, E ring connected to D ring.
We launched synthetic study of naphthacemycin A9 which has potent antibacterial activity against MRSA. As a result, we have accomplish the first total synthesis of naphthacemycin A9.
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| Free Research Field |
有機合成化学
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