2014 Fiscal Year Final Research Report
Development of bioactive compounds containing sugar moiety
| Project/Area Number |
24590020
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
|
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| Research Institution | Teikyo University |
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Principal Investigator |
|
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 軸不斉 / 糖化学 / 立体化学 / グリコシル化 |
|---|
| Outline of Final Research Achievements |
The total synthesis of Rebeccamycin and its derivatives was investigated.
The synthesized derivatives were analyzed by NMR and X-ray crystallography to elucidate their conformations.
In the course of the project, the new glycosylation utilizing Mitsunobu reaction was developed. The glycosylation was proceeded under neurtal conditions. It was revealed that the stereoselectivity was controlled by the polarity of the organic solvents.
|
| Free Research Field |
医薬化学
|
