2014 Fiscal Year Final Research Report
Diastereo- and Enantioselective Reaction of Carbocation
| Project/Area Number |
24590030
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Meiji Pharmaceutical University |
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Principal Investigator |
NOJI MASAHIRO 明治薬科大学, 薬学部, 講師 (80312073)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 希土類ルイス酸 / ジカルボニル化合物 / 錯体構造 / ジアステレオ選択性 / エナンチオ選択性 / カルボカチオン |
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| Outline of Final Research Achievements |
UV-Vis absorption spectrum and ESI-MS analysis revealed that diastereoselectivity of the rare earth metal triflate-catalyzed secondary benzylation of ketoester was controlled by the steric effect of 1:1:1 complex of the ketoester enol form, the ketoester keto form, and the lutetium ion.
Optically active rare earth metal Lewis acids and chiral thiourea catalysts were examined for the enantioselective reaction of the cationic species. Chiral thiourea-catalyzed reaction of the allylic alcohol and the sulfonamide gave quinoline derivative enantioselectively via a kinetic resolution of the quinoline product.
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| Free Research Field |
医師薬学
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