2014 Fiscal Year Final Research Report
Stereocontrolled synthesis
| Project/Area Number |
24590034
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | ゴニオシン / 天然物合成 / Pd触媒反応 / アセトゲニン / 不斉合成 / 立体化学 / 薬学 / 生物活性 |
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| Outline of Final Research Achievements |
Acetogenin is a class of polyketides of natural product obtained from Annonaceous plants. Although they exhibit diverse bioactivities, potent antitumor activity has particular attracted. Goniocin was isolated from a bark part of Goniothalamus giganteus in Thailand and has exhibited potent cytotoxic activity against several tumor cell lines at a level of nano molar. Goniocin is only a natural compound to possess a contiguous all trans-tris-THF ring system that consists of trans-threo-trans-threo-trans stereochemistry. In this research, the chemical total synthesis of this natural product has been accomplished.
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| Free Research Field |
有機合成化学
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