Search for new metabolic syndrome therapeutic candidates from Thai natural medicines

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590037
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Kinki University
• Principal Investigator: MORIKAWA Toshio 近畿大学, 薬学総合研究所, 准教授 (10340449)
• Co-Investigator(Renkei-kenkyūsha): NINOMIYA Kiyofumi 近畿大学, 薬学総合研究所, 講師 (10434862)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: タイ天然薬物 / メタボリックシンドローム / シーズ探索

Outline of Final Research Achievements

To investigate prevention and/or treatment for metabolic syndrome therapeutic candidates from Thai natural medicines, we examined following in vivo and in vitro pharmacological assays such as (i) suppressive effects on blood glucose and triglyceride elevation in sugar or olive oil-loaded mice, (ii) inhibitory effects on rat or human small intestinal α-glucosidases, (iii) suppressive effects on nitric oxide production in lipopolysaccharide-activated macrophages, and (iv) inhibitory effects on triglyceride content in high glucose-pretreated HepG2 cells, etc. As the results, several constituents were identified as the active compounds and their structural requirements and the mode of action were suggested.

Free Research Field

医歯薬学