Development of domino reactions utilizing unique property of N-alkoxy-amides and imines

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590039
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Kobe Pharmaceutical University
• Principal Investigator: UEDA Masafumi 神戸薬科大学, 薬学部, 准教授 (00340935)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ドミノ反応 / ラジカル / オキシム / ヒドラゾン / ヘテロ環 / 遷移金属触媒

Outline of Final Research Achievements

Domino reactions are greener reactions that allow for complex molecules to be constructed from a simple substrate in one operation in a straightforward, efficient, and elegant way without isolation of intermediates. The domino reaction of O-phenyl-conjugated oxime ether with an alkyl radical allows the construction of two heterocycles with three stereogenic centers as a result of the formation of two C-C bonds, a C-O bond, and a C-N bond in a single operation, leading to benzofuro[2,3-b]pyrroles, which are not easily accessible by existing synthetic methods. In addition, we also developed that a new method for the synthesis of isoquinolinones involving the palladium-catalyzed cyclization reaction.

Free Research Field

有機合成化学