Development of derivatization reagents for mass spectrometry and sensitive analysis of the biomolecules

2015 Fiscal Year Final Research Report

• Project/Area Number: 24590047
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: Santa Tomofumi 東京大学, 薬学研究科(研究院), 教授 (30187306)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 標識試薬 / 質量分析 / クロマトグラフィー / 生体分子 / 新生児マススクリーニング / LC/MS/MS

Outline of Final Research Achievements

Liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) is widely used method. In this research, the labeling reagents were synthesized to enhance the sensitivity and selectivity in LC/MS/MS. The reagents for LC/MS/MS enabled sensitive analysis of the biomolecules such as diseases markers. These methods were useful for the screening of the inherited metabolic disorders.

Free Research Field

分析化学